Anti-phospho-MLKL (Ser358)

Anti-phospho-MLKL (Ser358)
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Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG40184.100 100 µl - -

6 - 14 business days*

30 %
624.00€
436.80€
 
Protein function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed... more
Product information "Anti-phospho-MLKL (Ser358)"
Protein function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). [The UniProt Consortium]
Keywords: Anti-phospho-hMLKL, Anti-phospho-Mixed lineage kinase domain-like protein
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG40184

Properties

Application: IHC (paraffin), WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Phosphospecific peptide around Ser358 of Human MLKL
MW: 54 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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