Anti-phospho-MLKL (Ser345)

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ARG41492.50	50 µl		-	-	6 - 14 business days*		30 %	520.00€ 364.00€

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Protein function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed... more

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Product information "Anti-phospho-MLKL (Ser345)"

Protein function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). [The UniProt Consortium]

Keywords:	Anti-phospho-hMLKL, Anti-phospho-Mixed lineage kinase domain-like protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41492

Properties

Application:	IHC (paraffin)
Antibody Type:	Monoclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	mouse
Immunogen:	Phosphospecific peptide around Ser345 of Human MLKL
Format:	Purified