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![Anti-phospho-MDMX (Ser367)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES6213.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES6213.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a... more
Product information "Anti-phospho-MDMX (Ser367)"
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011], Protein function: Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.. Cellular localization: Nucleus.
Keywords: | Anti-phospho-MDM4, Anti-phospho-MDMX, Anti-phospho-Protein Mdmx, Anti-phospho-Protein Mdm4, Anti-phospho-Double minute 4 protein, Anti-phospho-p53-binding protein Mdm4, Anti-phospho-Mdm2-like p53-binding protein, MDMX (phospho Ser367) rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES6213 |
Properties
Application: | WB, IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | The antiserum was produced against synthesized peptide derived from human MDM4 around the phosphorylation site of Ser367. AA range:336-385 |
MW: | 80 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K10127 | Matching products |
UniProt ID : | O15151 | Matching products |
Gene ID | GeneID 4194 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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