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![Anti-phospho-Glycogen Synthase Kinase 3 alpha (Ser21) (GSK3a)](https://www.biomol.com/media/image/26/00/f2/600-401-429_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-429 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Constitutively active protein kinase that acts as a negative regulator in the... more
Product information "Anti-phospho-Glycogen Synthase Kinase 3 alpha (Ser21) (GSK3a)"
Protein function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. [The UniProt Consortium]
Keywords: | Anti-phospho-GSK3A, EC=2.7.11.1, Anti-phospho-GSK-3 alpha, EC=2.7.11.26, Anti-phospho-Glycogen synthase kinase-3 alpha, Anti-phospho-Serine/threonine-protein kinase GSK3A |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-429 |
Properties
Application: | ELISA, IFM, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | synthetic peptide corresponding to amino acids 16-25 of human GSK3 alpha |
MW: | 52 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K08822 | Matching products |
UniProt ID : | P49840 | Matching products |
Gene ID | GeneID 2931 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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