Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10601-1 | 1 each | - |
6 - 10 business days* |
564.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
GluR1 is a subunit of the AMPA ionotropic glutamate receptor, which is responsible for fast... more
Product information "Anti-GluR1 (Phospho-Ser845)"
GluR1 is a subunit of the AMPA ionotropic glutamate receptor, which is responsible for fast excitatory synaptic transmission in the CNS. AMPA receptors are composed of four subunits, GluR1, GluR2, GluR3, and GluR4, which combine into heterotetramers to form a cation-permeable pore in the plasma membrane. Each subunit has two isoforms with the primary isoform designated as flip and a second isoform generated through alternative splicing designated as flop. The GluR1 flip and flop isoforms do not affect desensitization or channel opening and closing kinetics. GluR1 can be phosphorylated by PKA at serine 845 (Ser845), which increases the peak open probability of the ion channel, and dephosphorylation is required for AMPA receptor endocytosis. GluR1 (phospho-Ser845) levels increase in the ventromedial prefrontal cortex (vmPFC) and nucleus accumbens (NAc) following cocaine-cue extinction. Levels of GluR1 (phospho-Ser845) are reduced following NMDA receptor activation in rat hippocampal slices and by amyloid-beta (Abeta) oligomers in primary mouse neurons. Cayman's GluR1 (Phospho-Ser845) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes Glur1 (phosphor-Ser845) at approximately 100 kDa from mouse, rat, and turtle samples.Synonyms: AMPA-selective Glutamate Receptor 1, GluR-1, GluR-A, GluA1. Immunogen: Phosphopeptide corresponding to amino residues surrounding the phospho-Ser845 of rat GluR1. Formulation: (Request formulation change), Affinity-purified polyclonal antibody from pooled serum. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Rabbit. Applications: IHC and WB. Cross Reactivity: (+) GluR1 (phosphor-Ser845), (-) Non-phosphorylated GluR1. Origin: Animal/Rabbit.
Keywords: | AMPA-selective Glutamate Receptor 1, GluA1, GluR-1, GluR-A |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10601 |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | rat |
Immunogen: | Phosphopeptide corresponding to amino residues surrounding the phospho-Ser845 of rat GluR1 |
Format: | Solid |
Database Information
KEGG ID : | K05197 | Matching products |
UniProt ID : | P19490 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
Viewed