Anti-gamma-H2AX

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-081A-T	10 µl (10 µg)		-		2 - 8 business days*		178.00€
A300-081A	100 µl (100 µg)		-		2 - 8 business days*		671.00€

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Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.... more

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Product information "Anti-gamma-H2AX"

Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. [The UniProt Consortium]

Keywords:	Anti-H2AX, Anti-H2AFX, Anti-H2a/x, Anti-Histone H2AX, Anti-Histone H2A.X
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-081A

Properties

Application:	WB, IHC, ICC-IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: bovine, dog, rabbit, guinea pig_10141, pig, rhesus monkey, gorilla, crab-eating macaque, chinese hamster, thirteen-lined ground squirrel, little brown bat)
Immunogen:	synthetic peptide. The epitope recongized by A300-081A-T maps to a region surrounding phosphorylated serine 139 of human histone H2AX using the numbering given for Swiss-Prot entry P16104 (GeneID 3014)
Format:	Antigen Affinity Purified