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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay36178-1 | 1 ml | - |
6 - 10 business days* |
645.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Interleukin-6 (IL-6) is a cytokine with roles in both the initiation and resolution of... more
Product information "Anti-citrullinated-Interleukin-6"
Interleukin-6 (IL-6) is a cytokine with roles in both the initiation and resolution of inflammatory responses. IL-6 is produced in response to an inflammatory event, induces recruitment of neutrophils to the site of inflammation, and signals through the membrane-bound IL-6 receptor (IL-6R) to upregulate the synthesis of acute phase proteins, lipolysis in the liver, and induced differentiation of T and B cells. Following initiation of this classical signaling pathway, a soluble form of IL-6R (sIL-6R) is released from neutrophils to promote recruitment of monocytes and macrophages, induction of fever via IL-6 action in the hypothalamus, and production of anti-inflammatory M2 macrophages to initiate tissue repair. Production of IL-6 is dysregulated in various chronic inflammatory diseases, including rheumatoid arthritis, Castleman disease, polymyalgia rheumatica, and giant cell arteritis. It also induces tumor growth and metastasis via activation of JAK/STAT signaling. Recombinant human IL-6 can be citrullinated at arginine residues by protein arginine deiminase 4 (PAD4) in vitro. Citrullinated IL-6 and anti-citrullinated peptide antibodies (ACPAs) reactive with citrullinated IL-6 have been found in synovial fluid and sera, respectively, from patients with rheumatoid arthritis. Cayman's Citrullinated Interleukin-6 Polyclonal Antibody can be used for ELISA and Western blot (WB) applications. The antibody recognizes citrullinated IL-6 at ~24 kDa from human samples.Synonyms: B Cell Stimulatory Factor 2, BSF-2, CDF, CTL Differentiation Factor, HGF, Hybridoma Growth Factor, IFN-beta2, IL-6, Interferon-beta2. Immunogen: Synthetic citrullinated peptide corresponding to an internal region of human IL-6. MW: ~24 kDa. Formulation: (Request formulation change), 1 ml of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, WB. Cross Reactivity: (+) Citrullinated IL-6. UniProt Accession #: P05231.
Keywords: | Anti-citrullinated-CDF, Anti-citrullinated-CDF, Anti-citrullinated-IL-6, Anti-citrullinated-IL-6, Anti-citrullinated-IFNB2, Anti-citrullinated-BSF-2, Anti-citrullinated-BSF-2, Anti-citrullinated-IFN-beta-2, Anti-citrullinated-IFN-beta-2, Anti-citrullinate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 36178 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic citrullinated peptide corresponding to an internal region of human IL-6 |
Format: | Peptide Affinity Purified |
Database Information
KEGG ID : | K05405 | Matching products |
UniProt ID : | P05231 | Matching products |
Gene ID | GeneID 3569 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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