iFluor(TM) 710 Anti-human CD8 Antibody *HIT8a*

iFluor(TM) 710 Anti-human CD8 Antibody *HIT8a*
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-100800K0 100 tests -

3 - 8 business days*

408.00€
ABD-100800K1 500 tests -

3 - 8 business days*

1,528.00€
 
Protein function: Integral membrane glycoprotein that plays an essential role in the immune... more
Product information "iFluor(TM) 710 Anti-human CD8 Antibody *HIT8a*"
Protein function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T- lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. [The UniProt Consortium]
Keywords: Anti-MAL, Anti-CD8A, Anti-CD8a, Anti-T-cell surface glycoprotein CD8 alpha chain, Anti-T-lymphocyte differentiation antigen T8/Leu-2
Supplier: AAT Bioquest
Supplier-Nr: 100800K

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: HIT8a
Conjugate: iFluor 710
Host: Mouse
Species reactivity: human
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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