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![Anti-VMAT2 (C-Term)](https://www.biomol.com/media/image/62/dc/a6/Cay29300-100_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29300-100 | 100 µl | - |
6 - 10 business days* |
617.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Vesicular monoamine transporter 2 (VMAT2) is a member of the SLC18 family of transporters that is... more
Product information "Anti-VMAT2 (C-Term)"
Vesicular monoamine transporter 2 (VMAT2) is a member of the SLC18 family of transporters that is encoded by SLC18A2 in humans. VMAT2 is expressed in monoaminergic neurons of the central and peripheral nervous systems and localizes to synaptic vesicles where it transports cytosolic dopamine (DA), serotonin (5-HT), norepinephrine (NE), and histamine into synaptic vesicles, regulating cytoplasmic levels and exocytosis of monoamine neurotransmitters. It consists of 12 transmembrane helices, which contain a luminal loop subject to N-glycosylation, as well as cytoplasmic N- and C-terminal domains that regulate monoamine transport and VMAT2 localization, respectively. Homozygous knockout of Slc18a2 completely eliminates brain DA, 5-HT, and NE and induces postnatal lethality in mice. Slc18a2+/- mice exhibit increased apomorphine-, cocaine-, amphetamine-, or ethanol-induced horizontal locomotor activity compared to wild-type mice. Slc18a2 overexpression decreases immobility time in the forced swim test and marble burying in mice. Slc18a2 overexpression also reduces the loss of dopaminergic neurons in a mouse model of Parkinson's disease induced by MPTP. SNPs in SLC18A2 have been found in individuals with bipolar disorder, schizophrenia, drug addiction, and Parkinson's disease. Cayman's VMAT2 (C-Term) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes VMAT2 at approximately 57 kDa from human and rat samples.Immunogen: Peptide from the intracellular C-terminal region of human VMAT2 conjugated to KLH. MW: ~57 kDa. Formulation: (Request formulation change), 100 µl of affinity-purified pooled sheep polyclonal antibody. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Sheep. Applications: WB.
Keywords: | Anti-SVMT, Anti-VAT2, Anti-SLC18A2, Anti-Monoamine transporter, Anti-Vesicular amine transporter 2, Anti-Solute carrier family 18 member 2, Anti-Synaptic vesicular amine transporter |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29300 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human, rat |
Immunogen: | Peptide from the intracellular C-terminal region of human VMAT2 conjugated to KLH |
MW: | ~57 kD |
Format: | Solid |
Database Information
KEGG ID : | K08155 | Matching products |
UniProt ID : | Q05940 | Matching products |
Gene ID | GeneID 6571 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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