Anti-VEGF-A (Capture/Detector), clone 4H2

Vascular endothelial growth factor (VEGF),also known as vascular permeability factor (VPF) and VEGF-A,is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects,including mediating increased vascular permeability,inducing angiogenesis,vasculogenesis and endothelial cell growth,promoting cell migration,inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability,thus it was originally referred to as vascular permeability factor. Protein function: [N-VEGF]: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia- mediated cell death. [The UniProt Consortium]