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![Anti-VDR](https://www.biomol.com/media/image/80/b7/7b/E-AB-60676-60_600x600.jpg)
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a... more
Product information "Anti-VDR"
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. Protein function: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis. [The UniProt Consortium]
Keywords: | Anti-VDR, Anti-NR1I1, Anti-Vitamin D3 receptor, Anti-1,25-dihydroxyvitamin D3 receptor, Anti-Nuclear receptor subfamily 1 group I member 1, VDR Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-60676 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant protein of human VDR |
Database Information
KEGG ID : | K08539 | Matching products |
UniProt ID : | P11473 | Matching products |
Gene ID | GeneID 7421 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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