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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES3756.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES3756.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates... more
Product information "Anti-V-ATPase D1"
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [pro Protein function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002, PubMed:28296633, PubMed:30374053). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: Membrane , Peripheral membrane protein , Cytoplasmic side . Lysosome membrane , Peripheral membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane , Peripheral membrane protein . Localizes to centrosome and the base of the cilium. .
Keywords: | Anti-p39, Anti-ATP6D, Anti-V-ATPase subunit d 1, Anti-V-ATPase AC39 subunit, Anti-32 kDa accessory protein, Anti-V-type proton ATPase subunit d 1, Anti-Vacuolar proton pump subunit d 1, Anti-V-ATPase 40 kDa accessory protein, V-ATPase D1 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES3756 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | The antiserum was produced against synthesized peptide derived from human V-ATPase D1. AA range:221-270 |
MW: | 40 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K02146 | Matching products |
UniProt ID : | P61421 | Matching products |
Gene ID : | GeneID 9114 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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