Anti-USP5/IsoT (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00313-T	10 µl (1 µg)		-		2 - 8 business days*		164.00€
IHC-00313	100 µl (10 µg)		-		2 - 8 business days*		623.00€

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Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference... more

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Product information "Anti-USP5/IsoT (IHC)"

Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. [The UniProt Consortium]

Keywords:	Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5, Anti-Ubiquitin carboxyl-terminal hydrolase 5, Anti-Ubiquitin-specific-processing protease 5
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00313

Properties

Application:	IHC, IHC-IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00313 maps to a region between residue 375 and 425 of human ubiquitin specific peptidase 5 (isopeptidase T) using the numbering given in entry CAA62690.1 (GeneID 8078).
Format:	Antigen Affinity Purified