Anti-Ubiquitin Hydrolase (UCHL1)

Anti-UCHL1 antibody is directed against human UCHL1 proteins. The antibody was purified from chicken eggs as an IgY fraction. Reactivity is expected from human, mouse, rat and bovine. Cross reactivity with UCHL1 from other species has not been determined. However, expect reactivity against most mammalian species based on high sequence homology. Protein function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. [The UniProt Consortium]