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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The modification of proteins with ubiquitin is an important cellular mechanism for targeting... more
Product information "Anti-UBE2D1"
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). [The UniProt Consortium]
Keywords: | Anti-SFT, Anti-UbcH5, Anti-UBE2D1, Anti-UBC4/5 homolog, Anti-Stimulator of Fe transport, Anti-Ubiquitin-protein ligase D1, Anti-Ubiquitin carrier protein D1, Anti-Ubiquitin-conjugating enzyme E2 D1, Anti-E2 ubiquitin-conjugating enzyme D1, UBE2D1 Polyclon |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-60521 |
Properties
Application: | WB, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant protein of human UBE2D1 |
Database Information
KEGG ID : | K06689 | Matching products |
UniProt ID : | P51668 | Matching products |
Gene ID : | GeneID 7321 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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