Anti-UBE1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-125A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A301-125A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for... more

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Product information "Anti-UBE1"

Protein function: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation- induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). [The UniProt Consortium]

Keywords:	Anti-UBA1, Anti-A1S9T, Anti-Protein A1S9, Anti-Ubiquitin-activating enzyme E1, Anti-Ubiquitin-like modifier-activating enzyme 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-125A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat, bovine, rabbit)
Immunogen:	synthetic peptide. The epitope recognized by A301-125A-T maps to a region between residue 1 and 50 of human ubiquitin-activating enzyme E1 using the numbering given in entry NP_003325.2 (GeneID 7317).
Format:	Antigen Affinity Purified