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![Anti-Tyrosine Hydroxylase (rat, native)](https://www.biomol.com/media/image/76/90/51/Cay29299-100_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29299-100 | 100 µl | - |
6 - 10 business days* |
628.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-DOPA, which is the... more
Product information "Anti-Tyrosine Hydroxylase (rat, native)"
Tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-DOPA, which is the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine. It assembles into tetramers, with each monomer comprised of an N-terminal regulatory domain with three serine residues at positions 19, 31, and 40 that are subject to regulatory phosphorylation, a central catalytic domain, and a C-terminal tetramerization domain. TH is expressed in dopaminergic neurons in the olfactory bulb, diencephalon, substantia nigra, ventral tegmental area, and retinal amacrine cells, adrenergic and noradrenergic cells in the hypothalamus, medulla, and locus coeruleus (LC), as well as sympathetic ganglia and adrenal chromaffin cells. Due to its expression in catecholaminergic neurons, TH has been used as a marker of these cells in the brain. Mutations in TH have been found in patients with tyrosine hydroxylase deficiency, infantile parkinsonism, and progressive infantile encephalopathy. Cayman's Tyrosine Hydroxylase (rat, native) Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes TH at approximately 60 kDa from human, mouse, rabbit, and rat samples.Synonyms: TH, Tyrosine 3-hydroxylase, Tyrosine 3-monooxygenase. Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma. MW: ~60 kDa. Formulation: (Request formulation change), 100 µl affinity-purified polyclonal antibody from pooled serum. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Sheep. Applications: ICC, IHC, WB.
Keywords: | TH, Tyrosine 3-hydroxylase, Tyrosine 3-monooxygenase |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29299 |
Properties
Application: | ICC, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human, mouse, rabbit, rat |
Immunogen: | Native rat tyrosine hydroxylase purified from pheochromocytoma |
MW: | 60 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K00501 | Matching products |
UniProt ID : | P04177 | Matching products |
Gene ID | GeneID 25085 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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