Anti-TrkC

0.5mg/ml if reconstituted with 0.2ml sterile DI water. NTRK3(Neurotrophic Tyrosine Kinase Receptor Type 3), also known as TRKC, is a protein that in humans is encoded by the NTRK3 gene. By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, McGregor et al.(1994) mapped the NTRK3 gene to 15q24-q25. Lamballe et al.(1991) isolated and characterized TRKC, a member of the TRK family of tyrosine protein kinase genes. They found that TRKC is preferentially expressed in the brain, in situ hybridization studies showed transcripts in the hippocampus, cerebral cortex, and the granular cell layer of the cerebellum. By functional studies in HeLa cells, Muinos-Gimeno et al.(2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3. Signaling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. The protein is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain. Protein function: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. [The UniProt Consortium]