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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T8171-94N.100 | 100 µg | - | - |
3 - 19 business days* |
675.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein... more
Product information "Anti-TRAF2 (TNF Receptor-associated Factor 2, TRAF 2, TRAF2, MGC-45012, TRAP, Tumor Necrosis Factor"
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. , Recommended Dilutions: Peptide ELISA Titer: 1:128,000, Western Blot: 0.1-0.3ug/ml ~50kD band observed in Human Ovary lysates (calculated MW of 55.9kD according to NP_066961.2). In transfected HEK293 transiently expressing Human TRAF2 a band of approx. 60kD is observed. This band is not observed in the non-transfected HEK293. The endogenous 48kD protein is observed in both., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=6.3.2.-, Anti-TNF receptor-associated factor 2, Anti-E3 ubiquitin-protein ligase TRAF2, Anti-Tumor necrosis factor type 2 receptor-associated protein 3 |
Supplier: | United States Biological |
Supplier-Nr: | T8171-94N |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Goat |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to C-KMEAKNSYVRDD, from the C Terminus of human TRAF2 (NP_066961.2). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K03173 | Matching products |
UniProt ID : | Q12933 | Matching products |
Gene ID : | GeneID 7186 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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