Anti-TP Receptor (human) FITC

Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. The short half-life of TXA2 ensures local action whether generated by vascular endothelial cells or by platelets and confers physiologically beneficial or deleterious effects under inflammatory situations. TXA2 elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor. This receptor can also bind prostaglandin H2 and isoprostanes and was first cloned from human placenta and the platelet-like MEG-01 cell line. The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.Synonyms: Thromboxane A2 Receptor, TXA2 Receptor. Immunogen: Synthetic peptide from the C-terminal region of human TP receptor. Formulation: (Request formulation change), 100 µl of fluorescein-labeled, peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: FC. UniProt Accession #: P21731. Origin: Animal/Rabbit.