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![Anti-TLR9 (Toll Like Receptor 9, CD289)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T8050-97C.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TLR9 is a 145-150kD member of the Toll-like receptor family of molecules. It is expressed by... more
Product information "Anti-TLR9 (Toll Like Receptor 9, CD289)"
TLR9 is a 145-150kD member of the Toll-like receptor family of molecules. It is expressed by colonic epithelium, CD123+ plasmacytoid dendritic cells, and transitional B cells, and responds to unmethylated DNA CpG motifs that exhibit either a GTCGTT sequence (in human), or a GACGTT sequence (in mouse). TLR9 is found in the ER, and translocates to either the cell membrane, or to lysosomes where it binds bacterial DNA. Precursor human TLR9 is a type I transmembrane protein 1032aa in length. It possesses a 793aa extracellular region that contains 26 LRRs (aa26-818), plus a 193aa cytoplasmic domain. The full-length 150kD form is suggested to be ligand-binding but nonsignaling. The active form is believed to be an 80kD cleavage product found in the endosome compartment. There are multiple splice forms. One contains a deletion of aa2-16, a second possesses an alternate start site at aa58, while a third and fourth show alternative start sites aa23 and 24 upstream of the standard site. Over aa64-189, human TLR9 shares 76aa identity with mouse TLR9. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 2.5ug labels 10e6 cells, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-Toll-like receptor 9 |
Supplier: | United States Biological |
Supplier-Nr: | T8050-97C |
Properties
Application: | FC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa64-189 from human TLR9 expressed in E. coli (Q9NR96). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K10161 | Matching products |
UniProt ID : | Q9NR96 | Matching products |
Gene ID | GeneID 54106 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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