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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T8050-53L.100 | 100 µg | - | - |
3 - 19 business days* |
719.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins... more
Product information "Anti-TLR6 (Toll-like Receptor 6, CD286) (PE)"
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88:interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. the aa sequence of human TLR6 is most similar to hTLR1 with 69% identity at the aa level. Human TLR6 consists of a predicted 807aa with a molecular weight of approximately 92kD (3). Human and mouse TLR6 share an aa identity of 73%. TLR6 activates both NF-kB and c-Jun N-terminal Kinase (JNK). the aa in the cytoplasmic domain of IL-1 receptor, which are critical for NF-kB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6 (4). TLR6 is predominantly expressed in spleen, thymus, ovary, and lung (3). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry (Intracellular): 0.5-1ug/10e6 cells, Optimal dilutions to be determined by the researcher. Positive Control: Ramos, human PBMCs, Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Keywords: | Anti-Toll-like receptor 6 |
Supplier: | United States Biological |
Supplier-Nr: | T8050-53L |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 11E375 |
Conjugate: | Phycoerythrin |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to aa408-424 of human TRL6. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K10169 | Matching products |
UniProt ID : | Q9Y2C9 | Matching products |
Gene ID : | GeneID 10333 | Matching products |
Handling & Safety
Storage: | +4°C (do not freeze) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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