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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-10-3013-25 | 25 µg | - |
3 - 11 business days* |
149.00€
|
|||
ABE-10-3013-100 | 100 µg | - |
3 - 11 business days* |
418.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Toll-like receptor 5 (TLR5) plays a fundamental role in pathogen recognition and downstream... more
Product information "Anti-TLR5 (Clone: ABM22G1)"
Toll-like receptor 5 (TLR5) plays a fundamental role in pathogen recognition and downstream signaling to induce effective immunity. It is well expressed in major old tissues including lung, skin, intestine, and spleen. TLR5 is present in synovial of patients with rheumatoid arthritis (RA), act as novel mediator of innate immunity-induced osteoclastogenesis and bone loss. TLR5 is a receptor for flagellin and is present on the basolateral surface of intestinal epithelial cells. It is involved in the migration of intestinal epithelial cells through activation of the p38 MAPK pathway. TLR5-mediated signaling specifically enhanced the maturation of lung dendritic cells. TLR5 influences the progression and outcome of ovarian, sarcoma, and luminal breast tumors. Mutations in TLR5 have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. Protein function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [The UniProt Consortium]
Keywords: | Anti-TLR5, Anti-TIL3, Anti-Toll-like receptor 5, Anti-Toll/interleukin-1 receptor-like protein 3, Monoclonal Antibody to TLR5 (Clone: ABM22G1) |
Supplier: | Abeomics |
Supplier-Nr: | 10-3013 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | ABM22G1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A partial length recombinant TLR5 protein was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10168 | Matching products |
UniProt ID : | O60602 | Matching products |
Gene ID : | GeneID 7100 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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