Anti-TLR3 (Clone: ABM15D5)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-10-3004-25 25 µg -

3 - 11 business days*

149.00€
ABE-10-3004-100 100 µg -

3 - 11 business days*

418.00€
 
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response.... more
Product information "Anti-TLR3 (Clone: ABM15D5)"
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages. Protein function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. [The UniProt Consortium]
Keywords: Anti-TLR3, Anti-CD283, Anti-Toll-like receptor 3, Monoclonal Antibody to TLR3 (Clone: ABM15D5)
Supplier: Abeomics
Supplier-Nr: 10-3004

Properties

Application: FC
Antibody Type: Monoclonal
Clone: ABM15D5
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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