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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay37075-50 | 50 µl | - | - |
6 - 10 business days* |
179.00€
|
||
Cay37075-100 | 100 µl | - | - |
6 - 10 business days* |
305.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Thioredoxin 2 (Trx2) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin... more
Product information "Anti-Thioredoxin 2 Rabbit Monoclonal (Clone 054)"
Thioredoxin 2 (Trx2) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular redox homeostasis. It is ubiquitously expressed, with the highest levels of expression in metabolically active tissues such as the heart, skeletal muscle, testis, kidney, adrenal gland, and brain, and is localized to the mitochondria. Trx2 contains two active site cysteine residues, but lacks the additional structural cysteines present in Trx1 that participate in dimerization. During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH. Trx2 is upregulated by TNF-alpha and reactive oxygen species (ROS), inhibits TNF-alpha-induced NF-kappaB activation, and inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1). Homozygous disruption of the gene encoding Trx2, Txn2, causes exencephaly and is embryonic lethal in mice. Trx2 deficiency is associated with premature neurodegeneration. Cayman's Thioredoxin 2 Rabbit Monoclonal Antibody (Clone 054) can be used for immunohistochemistry (IHC).Synonyms: Mitochondrial Thioredoxin, mtTrx, Trx2, Txn2. Immunogen: Recombinant human Trx2. Clone Designation: 054. Formulation: (Request formulation change), 50 or 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: IHC. Cross Reactivity: (+) Trx2. UniProt Accession #: Q99757.
Keywords: | Anti-TXN2, Anti-TRX2, Anti-MTRX, Anti-MTRX, Anti-Mt-Trx, Anti-Mt-Trx, Anti-Thioredoxin-2, Anti-Thioredoxin-2, Anti-Thioredoxin, mitochondrial, Anti-Thioredoxin, mitochondrial |
Supplier: | Cayman Chemical |
Supplier-Nr: | 37075 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | 054 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant human Trx2 |
Format: | Purified |
Database Information
KEGG ID : | K03671 | Matching products |
UniProt ID : | Q99757 | Matching products |
Gene ID : | GeneID 25828 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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