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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T1019-47A.100 | 100 µl | - | - |
3 - 19 business days* |
688.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that... more
Product information "Anti-TAR DNA Binding Protein 43 (TARDBP, TDP-43, TDP43)"
HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression, by the transactivator Tat, is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. Recently it has been shown that TDP-43 accumulates abnormally in post-mortem brain tissue from individuals diagnosed with both ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This observation provides a long sought connection between two disease that often over-lap clinically. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/ml, Immunofluorescence (IC): 1:100-1:1000. A nuclear signal is present in MCF-7 cells., Optimal dilutions to be determined by the researcher. Positive Control: Hela Whole Cell Extract, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-TDP43, Anti-TARDBP, Anti-TDP-43, Anti-TAR DNA-binding protein 43 |
Supplier: | United States Biological |
Supplier-Nr: | T1019-47A |
Properties
Application: | ICC, IF, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | chicken, human, monkey, mouse, xenopus |
Immunogen: | A synthetic peptide to a C-terminal region [within residues 350-414] of the human TARDBP protein. [Swiss-Prot# Q13148]. Homology: 100% with human, monkey, mouse, chicken, Xenopus, and Zebrafish. |
Purity: | Purified by immunoaffinity chromatography. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K23600 | Matching products |
UniProt ID : | Q13148 | Matching products |
Gene ID : | GeneID 23435 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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