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![Anti-ST2 (human) (ATTO 647N)](https://www.biomol.com/media/image/53/df/e5/AG-25A-0058YTS-T100_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-25A-0058YTS-T100 | 100 tests | - |
3 - 9 business days* |
369.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Receptor for interleukin-33 (IL-33), signaling requires association of the... more
Product information "Anti-ST2 (human) (ATTO 647N)"
Protein function: Receptor for interleukin-33 (IL-33), signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. [The UniProt Consortium] ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naïve state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
Keywords: | Anti-DER4, Anti-IL1RL1, Anti-Protein ST2, Anti-Interleukin-1 receptor-like 1, Anti-IL-33 Receptor, Anti-Interleukin-33 Receptor |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-25A-0058YTS |
Properties
Application: | ELISA, FC, WB |
Antibody Type: | Polyclonal |
Conjugate: | ATTO 647N |
Species reactivity: | human |
Immunogen: | Recombinant human soluble ST2 |
Format: | Purified |
Database Information
KEGG ID : | K05171 | Matching products |
UniProt ID : | Q01638 | Matching products |
Gene ID | GeneID 9173 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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