Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
![Anti-sPLA2 (mouse Type V)](https://www.biomol.com/media/image/ae/97/6c/Cay160512-1_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay160512-1 | 500 µl | - |
6 - 10 business days* |
422.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Secretory phospholipase A2 (sPLA2) (Type V) is a calcium-dependent phospholipase A2 superfamily... more
Product information "Anti-sPLA2 (mouse Type V)"
Secretory phospholipase A2 (sPLA2) (Type V) is a calcium-dependent phospholipase A2 superfamily member that is encoded by PLA2G5 in humans. It is composed of a highly conserved calcium-binding loop, a heparin-binding domain, and a C-terminal domain that contains a catalytic histidine-aspartic acid dyad and cationic residues that are essential for cell membrane association. Pla2g5 is constitutively expressed in the heart, lung, and spleen and is induced by proinflammatory stimuli in a variety of immune cells and tissues. Upon activation, sPLA2 (Type V) is released into the extracellular space where it acts in a paracrine or autocrine manner to catalyze the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating the free fatty acid and lysophospholipid, which serve as substrates for the synthesis of bioactive lipid metabolites. Pla2g5-/- mice have decreased airway and bronchoalveolar lavage fluid (BALF) neutrophil infiltration in a model of acute lung injury induced by LPS. Neonatal mice overexpressing Pla2g5 have increased BALF prostaglandin E2 (PGE2, Cay-14010) levels, as well as reduced lung surfactant levels, leading to respiratory failure and death by postnatal day one. SNPs in PLA2G5 are associated with increased plasma LDL and total cholesterol levels in individuals with type 2 diabetes. Cayman's sPLA2 (mouse Type V) Polyclonal Antibody can be used for Western blot applications. The antibody recognizes sPLA2 (Type V) at 16 kDa from human, mouse, and rat samples.Synonyms: Secretory Phospholipase A2 (mouse Group V). Immunogen: Synthetic peptide from an internal region of mouse protein. Formulation: (Request formulation change), 500 µl of peptide-affinity purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (-) cPLA2, (-) iPLA2, (-) Bee venom sPLA2, (-) Human synovial sPLA2. UniProt Accession #: P97391. Origin: Animal/Mouse.
Keywords: | Anti-Pla2g5, Anti-PLA2-10, Anti-PLA2-10, Anti-Phospholipase A2 group V, Anti-Phospholipase A2 group V, Anti-Phosphatidylcholine 2-acylhydrolase 5, Anti-Phosphatidylcholine 2-acylhydrolase 5 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 160512 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, murine, rat |
Immunogen: | Synthetic peptide from an internal region of mouse protein |
Format: | Peptide Affinity Purified |
Database Information
KEGG ID : | K01047 | Matching products |
UniProt ID : | P97391 | Matching products |
Gene ID | GeneID 18784 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed