Anti-SOX2

0.5mg/ml if reconstituted with 0.2ml sterile DI water. SRY (sex determining region Y)-box 2 is a transcription factor that is essential for maintaining self-renewal, or pluripotency of undifferentiated embryonic stem cells. The protein is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. It was found that SOX2 can regulate OCT3/4 expression and maintains ES pluripotency through upstream transcription factors. It is identified as a lineage-survival oncogene in lung and esophageal squamous cell carcinoma. In addition to those, it has a critical role in maintenance of embryonic and neural stem cells and holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine. Protein function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. [The UniProt Consortium]