Anti-Soluble Epoxide Hydrolase

Anti-Soluble Epoxide Hydrolase
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010146-1 1 each -

6 - 10 business days*

431.00€
 
Soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold enzyme family that... more
Product information "Anti-Soluble Epoxide Hydrolase"
Soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold enzyme family that catalyzes the hydrolysis of bioactive fatty acid epoxides to inactive vicinal diols. It is a homodimer in which each subunit is composed of two domains, a C-terminal epoxide hydrolase domain and an N-terminal phosphatase domain. sEH is localized to the cytoplasm or to peroxisomes in a tissue-specific manner and is found in various tissues, including skin, lung, uterus, kidney, brain, and myocardium. sEH is also expressed in the vasculature and inhibition of sEH attenuates pathogenic vascular remodeling and hypertension via preservation of cardioprotective epoxyeicosatrienoic acids (EETs) in rat models of atherosclerosis and hypertension, respectively. Inhibition of sEH also has a protective role in various diseases, including inflammatory bowel disease, osteoarthritis, seizure, stroke, and Alzheimer's disease, as well as in various chronic pain states. Cayman's Soluble Epoxide Hydrolase Polyclonal Antibody can be used for Western blot. The antibody recognizes sEH at approximately 64 kDa from human, mouse, and rat samples.Synonyms: Cytosolic Epoxide Hydrolase (CEH), EPHX2, Epoxide Hydrolase 2, sEH. Immunogen: Synthetic peptide from the internal region of human sEM. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: WB. UniProt Accession #: P34913. Origin: Animal/Rabbit.
Keywords: Anti-CEH, Anti-CEH, Anti-Epoxide hydratase, Anti-Epoxide hydratase, Anti-Lipid-phosphate phosphatase, Anti-Lipid-phosphate phosphatase, Anti-Cytosolic epoxide hydrolase 2, Anti-Cytosolic epoxide hydrolase 2, Anti-Bifunctional epoxide hydrolase 2 {ECO:0000
Supplier: Cayman Chemical
Supplier-Nr: 10010146

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, murine, rat (Expected: bovine, swine, canine, chicken)
Immunogen: Synthetic peptide from the internal region of human sEM
Format: Solid

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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