Anti-Smoothened

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-MG0S	25 µl		-	-	6 - 10 business days*		180.00€
600-401-MG0	100 µg		-	-	6 - 10 business days*		719.00€

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This affinity purified antibody is directed against human SMO. This product was affinity... more

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Product information "Anti-Smoothened"

This affinity purified antibody is directed against human SMO. This product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse and rat. Protein function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. [The UniProt Consortium]

Keywords:	Anti-SMO, Anti-SMOH, Anti-Protein Gx, Anti-Smoothened homolog
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-MG0

Properties

Application:	ELISA, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	synthetic peptide corresponding to an internal portion of human Smoothened conjugated to Keyhole Limpet Hemocyanin (KLH).
Format:	Purified