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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-CAB19253.20 | 20 µl | - | - |
9 - 20 business days* |
149.00€
|
||
G-CAB19253.100 | 100 µl | - |
9 - 20 business days* |
566.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Serine/threonine protein kinase involved in both mRNA surveillance and... more
Product information "Anti-SMG1"
Protein function: Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense- mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. [The UniProt Consortium]
Keywords: | Anti-SMG-1, Anti-hSMG-1, EC=2.7.11.1, Anti-Lambda-interacting protein, Anti-Serine/threonine-protein kinase SMG1, Anti-Lambda/iota protein kinase C-interacting protein, Anti-Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1, SMG1 Monoclonal |
Supplier: | Assay Genie |
Supplier-Nr: | CAB19253 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Database Information
UniProt ID : | Q96Q15 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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