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![Anti-Shh (Sonic HedgeHog)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
S1012-96P.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are... more
Product information "Anti-Shh (Sonic HedgeHog)"
The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are structurally related and share a high degree of amino-acid sequence identity (e.g., Shh and Ihh are 93% identical). The biologically active form of Hh molecules is obtained by autocatalytic cleavage of their precursor proteins and corresponds to approximately the N-terminal one half of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can substitute for each other in experimental systems. Sonic Hedgehog, which is expressed only during embryogenesis, is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the Sonic Hedgehog protein of Drosophila, this protein is the most similar. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry and Neutralization. Other applications not tested. Recommended Dilution: ELISA (Capture): 2-8ug/ml, ELISA (Detection): 0.5-2ug/ml, Immunohistochemistry: 8-25ug/ml using perfusion fixed frozen sections of mouse brain and embryos., Western Blot: 2ug/ml on human and mouse brain and stomach tissue, Neutralization: Measured by its ability to neutralize sonic hedgehog alkaline phosphatase production in C3H10TT1/2 mouse embryonic bibroblast cell line. ND50 is typically 5-15ug/ml in the presence of 5ug/ml recombinant mouse sonic hedgehog N-terminus., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Shh, Anti-Hhg1 |
Supplier: | United States Biological |
Supplier-Nr: | S1012-96P |
Properties
Application: | ELISA, IHC, Neutr., WB |
Antibody Type: | Monoclonal |
Clone: | 171018 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | human, mouse |
Immunogen: | Recombinant protein corresponding to aa25-198 of mouse sonic hedgehog expresssed in E coli (Q62226) |
Format: | Affinity Purified |
Database Information
KEGG ID : | K11988 | Matching products |
UniProt ID : | Q62226 | Matching products |
Gene ID | GeneID 20423 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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