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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
S1013-31E3.100 | 100 µg | - | - |
3 - 19 business days* |
675.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B... more
Product information "Anti-SH2D1A (SH2 Domain Protein 1A, Duncan Disease SH2-protein, DSHP, EBVS, FLJ18687, FLJ92177, HGNC"
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. , Recommended Dilutions: Peptide ELISA Titer: 1:16,000, Western Blot: 0.3-1ug/ml ~16kD band observed in Human Thymus lysates (calculated MW of 14.2xkD according to NP_002342.1). In transfected HEK293 transiently expressing SH2D1A a band of approx. 16kD is observed. This band is not observed in the non-transfected HEK293., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-SLAM-associated protein, Anti-Duncan disease SH2-protein, Anti-SH2 domain-containing protein 1A, Anti-T-cell signal transduction molecule SAP, Anti-Signaling lymphocytic activation molecule-associated protein |
Supplier: | United States Biological |
Supplier-Nr: | S1013-31E3 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Goat |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to C-HKRYFRKIKN, from the internal region of human SH2D1A (NP_002342.1, NP_001108409.1). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K07990 | Matching products |
UniProt ID : | O60880 | Matching products |
Gene ID : | GeneID 4068 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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