Anti-SGPL1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA021125.25	25 µl		-		7 - 10 business days*		300.00€
ATA-HPA021125.100	100 µl		-		7 - 10 business days*		421.00€

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Protein function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate,... more

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Product information "Anti-SGPL1"

Protein function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro- inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 85% and to rat: 88%

Keywords:	Anti-hSPL, Anti-S1PL, Anti-SPL 1, Anti-SP-lyase 1, Anti-Sphingosine-1-phosphate lyase 1, Anti-Sphingosine-1-phosphate aldolase
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA021125

Properties

Application:	WB, IHC, ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: SRDFDIYRLS NLMTAKGWNL NQLQFPPSIH FCITLLHARK RVAIQFLKDI RESVTQIMKN PKAKTTGMGA IYGMAQTTVD RNMVAELSSV FLDSLYSTDT VTQGSQMNGS PK (ATA-APrEST74227)