Anti-set-4

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3) (PubMed:22393255, PubMed:23028348). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes (PubMed:22393255, PubMed:23028348, PubMed:26641248). Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway (PubMed:23884442). [The UniProt Consortium]