Anti-Semaphorin 4D/CD100 (Capture)

CD100 (also known as SEMA4D),a 150 kDa homodimer,belongs to the family of immune semaphorins,and CD100 is abundantly expressed on resting T cells,NK cells,and antigen-presenting cells. As a transmembrane glycoprotein,it is digested to its soluble form,sCD100,by specific matrix metalloproteinases. CD100 has been reported that the expression levels of CD100,and one of its receptors,plexin-B1 (PLXNB1),are increased in head and neck,prostate,colon,breast,and lung cancers,and the interaction between them provides oncogenic signaling essential for tumor growth and metastasis. Protein function: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system, induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). [The UniProt Consortium]