Anti-RSPO1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-EC3	100 µg		-	-	6 - 10 business days*		834.00€

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Anti-RSPO1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more

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Product information "Anti-RSPO1"

Anti-RSPO1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with RSPO1 from other sources has not been determined. Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. [The UniProt Consortium]

Keywords:	Anti-RSPO1, Anti-hRspo1, Anti-R-spondin-1, Anti-Roof plate-specific spondin-1
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-EC3

Properties

Application:	ELISA, IHC, IFM, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	16 amino acid synthetic peptide from near the N-terminus of human RSPO1.
Format:	Purified