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Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
*1
*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG63225.100 | 100 µg | - | - |
6 - 14 business days* |
30 %
|
784.00€
548.80€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates... more
Product information "Anti-RNF31 / ZIBRA, C-terminal"
Protein function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. [The UniProt Consortium]
Keywords: | Anti-HOIP, Anti-RNF31, Anti-ZIBRA, EC=6.3.2.-, Anti-RING finger protein 31, Anti-HOIL-1-interacting protein, Anti-E3 ubiquitin-protein ligase RNF31, Anti-Zinc in-between-RING-finger ubiquitin-associated domain protein |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG63225 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Goat |
Species reactivity: | human (Expected: canine, swine) |
Immunogen: | C-EEVPLGQSIPRRRK |
Format: | Ammonium Sulfate Precipitated |
Database Information
KEGG ID : | K11974 | Matching products |
UniProt ID : | Q96EP0 | Matching products |
Gene ID : | GeneID 55072 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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