Anti-RIP3

Anti-RIP3 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with RIP3 with Rat and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with RIP3 from other sources has not been determined. RIP3 antibody detects murine RIP3. Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-κ.B activation. Overexpression of RIP3 induces apoptosis and NF-κ.B activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues. Anti-RIP3 antibodies are ideal for investigators involved in NFkappaB and Kinase and Phosphatase research.