Anti-RIP1

Anti-RIP1
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Promotion:

Save 30% on all primary antibodies by Arigo Biolaboratories!

*1
*1 Offer expires 16/12/2024
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG56458.50 50 µg - -

6 - 14 business days*

30 %
520.00€
364.00€
 
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals... more
Product information "Anti-RIP1"
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. [The UniProt Consortium]
Keywords: Anti-RIP, Anti-RIP-1, Anti-RIPK1, EC=2.7.11.1, Anti-Cell death protein RIP, Anti-Receptor-interacting protein 1, Anti-Serine/threonine-protein kinase RIP, Anti-Receptor-interacting serine/threonine-protein kinase 1
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG56458

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Partial recombinant protein around aa. 316-671 of Human RIP1
MW: 76 kD
Format: Antigen Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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