Anti-RIMBP3, NT (RIMBP3, KIAA1666, RIMBP3A, RIMS-binding protein 3A, RIMS-binding protein 3.1)

RIM-binding proteins (RIMBPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. RIMBP3 has been identified as a novel manchette-associated protein, and three members of RIMBP3 are known to exist: RIMBP3A, RIMBP3B and RIMBP3C. Each form of RIMBP3 exists as a large multidomain protein encoding three SH3-domains and two to three fibronectin III repeats. RIMBP3 plays a role in spermatid development and is required for normal sperm morphology and male fertility. RIMBP3 is found at high levels outside of the nervous system, with especially high expression in testis. RIMBP3C (RIMS binding protein 3C), also known as RIMBP3.3, or RIM-BP3.3, is a 1545 amino acid protein. Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.