Anti-Retinoic Acid Receptor beta, clone 336

Anti-Retinoic Acid Receptor beta antibody detects Retinoic Acid Receptor beta. Retinoic Acid Receptor beta antibodies was Protein G purified. This antibody is directed against human retinoic acid receptor beta protein. Expect reactivity with RAR beta from the following species is prediceted based on 100% sequence homology: canine, guinea pig, mouse and rat. Cross reactivity from other sources has not been determined. Protein function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. [The UniProt Consortium]