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![Anti-Retinoblastoma (Rb), clone 3A38](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
R1660-05.100 | 100 µl | - | - |
3 - 19 business days* |
675.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The retinoblastoma tumor suppressor protein, Rb, regulates cell proliferation by controlling... more
Product information "Anti-Retinoblastoma (Rb), clone 3A38"
The retinoblastoma tumor suppressor protein, Rb, regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle (1). Rb has three functionally distinct binding domains and interacts with critical regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase, and proteins with a conserved LXCXE motif (2-4). Cell cycle-dependent phosphorylation by cdk's inhibits Rb target binding, thus allowing cell cycle progression (5). Rb inactivation and subsequent cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (6). Specificity of different cdk/cyclin complexes has been observed in vitro (6-8) and cyclin D1 is required for Ser780 phosphorylation in vivo (9). Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry, Immunofluorescence and Flow Cytometry. Other applications not tested. Recommended Dilution: Western Blot: 1:2000, incubate membrane with diluted antibody in 5% nonfat dry milk, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Immunoprecipitation: 1:100, Immunohistochemistry (Paraffin): 1:100, Immunocytochemistry (for IF): 1:200, Flow Cytometry: 1:400, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-RB1, Anti-pRb, Anti-pp110, Anti-p105-Rb, Anti-Retinoblastoma-associated protein |
Supplier: | United States Biological |
Supplier-Nr: | R1660-05 |
Properties
Application: | ELISA, FC, ICC, IF, IHC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 3A38(4H1) |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | bovine, human, monkey, swine |
MW: | 11 kD |
Format: | Purified |
Database Information
KEGG ID : | K03083 | Matching products |
UniProt ID : | P49841 | Matching products |
Gene ID | GeneID 2932 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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