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![Anti-Recombinant ALIX, clone R03-8C2](https://www.biomol.com/media/image/7b/4f/e0/E-AB-81456-50_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-81456.50 | 50 µl | - |
7 - 16 business days* |
158.00€
|
|||
E-AB-81456.100 | 100 µl | - |
7 - 16 business days* |
257.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of... more
Product information "Anti-Recombinant ALIX, clone R03-8C2"
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. Protein function: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier. [The UniProt Consortium]
Keywords: | Anti-Hp95, Anti-AIP1, Anti-PDCD6IP, Anti-PDCD6-interacting protein, Anti-ALG-2-interacting protein X, Anti-ALG-2-interacting protein 1, Anti-Programmed cell death 6-interacting protein, Recombinant ALIX Monoclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-81456 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | R03-8C2 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, hamster |
Immunogen: | Recombinant protein of human ALIX |
Database Information
KEGG ID : | K12200 | Matching products |
UniProt ID : | Q8WUM4 | Matching products |
Gene ID | GeneID 10015 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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