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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES3328.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES3328.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor... more
Product information "Anti-RARbeta"
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014], Protein function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: Nucleus . Cytoplasm ., [Isoform Beta-1]: Nucleus., [Isoform Beta-2]: Nucleus., [Isoform Beta-4]: Cytoplasm.
Keywords: | Anti-HAP, Anti-RARB, Anti-RAR-beta, Anti-RAR-epsilon, Anti-HBV-activated protein, Anti-Retinoic acid receptor beta, Anti-Nuclear receptor subfamily 1 group B member 2, RARbeta rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES3328 |
Properties
Application: | WB, IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor beta. AA range:331-380 |
MW: | 50 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K08528 | Matching products |
UniProt ID : | P10826 | Matching products |
Gene ID | GeneID 5915 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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