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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-553A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-553A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1)... more
Product information "Anti-Raptor"
Protein function: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. [The UniProt Consortium]
Keywords: | Anti-RPTOR, Anti-Raptor, Anti-KIAA1303, Anti-Regulatory-associated protein of mTOR, Anti-p150 target of rapamycin (TOR)-scaffold protein |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-553A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: bovine, guinea pig, swine, panda, rhesus monkey, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, naked mole rat, gray short-tailed opossum, zebra finch) |
Immunogen: | synthetic peptide. The epitope recognized by A300-553A-T maps to a region between residues 1 and 50 of human Regulatory Associated Protein of mTOR using the numbering given in entry AAM09075.1 (GeneID 57521). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K07204 | Matching products |
UniProt ID : | Q8N122 | Matching products |
Gene ID : | GeneID 57521 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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