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![Anti-PSMB7 / Proteasome 20S beta 7, clone 3H6C8](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ7689 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Proteasome subunit beta type-7 as known as... more
Product information "Anti-PSMB7 / Proteasome 20S beta 7, clone 3H6C8"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Proteasome subunit beta type-7 as known as 20S proteasome subunit beta-2 is a protein that in humans is encoded by the PSMB7 gene. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. Protein function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. [The UniProt Consortium]
Keywords: | Anti-Z, Anti-PSMB7, Anti-Macropain chain Z, Anti-Proteasome subunit Z, Anti-Proteasome subunit beta type-7, Anti-Multicatalytic endopeptidase complex chain Z, PSMB7 Antibody / Proteasome 20S beta 7 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ7689 |
Properties
Application: | WB, FC |
Antibody Type: | Monoclonal |
Clone: | 3H6C8 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat, monkey |
Immunogen: | E. coli-derived recombinant human protein (amino acids D17-S277) |
Format: | Purified |
Database Information
KEGG ID : | K02739 | Matching products |
UniProt ID : | Q99436 | Matching products |
Gene ID | GeneID 5695 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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