Anti-PSMA

Prostate-specific membrane antigen (PSMA) is expressed in normal and malignant prostatic epithelium and in a subset of non-prostatic tissues. In prostate cancer,PSMA expression has been shown to correlate with disease progression,with highest levels expressed in hormone-refractory and metastatic disease. The cellular localization of PSMA is cytoplasmic and/or membranous. Protein function: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. [The UniProt Consortium]