Anti-Prostate Specific Antigen PSA, clone A67-B/E3

1 mg/ml in sterile PBS, BSA free, sodium azide free. This antibody recognizes a single protein of 33-34kDa, identified as the prostate specific antigen (PSA). The antibody is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. Prostate specific antigen (PSA) is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia. Protein function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. [The UniProt Consortium]